Clemson University (/ˈklɛmp.sən, ˈklɛm.zən/) is a public land-grant research university in Clemson, South Carolina. Founded in 1889, Clemson is the second-largest university in student population in South Carolina. For the fall 2019 semester, the university enrolled a total of 20,195 undergraduate students and 5,627 graduate students, and the student/faculty ratio was 18:1. Clemson's 1,400-acre campus is in the foothills of the Blue Ridge Mountains. The campus now borders Lake Hartwell, which was formed by the dam completed in 1962. The university manages the nearby 17,500-acre Clemson Experimental Forest that is used for research, education, and recreation.

Clemson University consists of seven colleges: Agriculture, Forestry and Life Sciences; Architecture, Arts and Humanities; The Wilbur O. and Ann Powers College of Business; Behavioral, Social and Health Sciences; Education; Engineering, Computing and Applied Sciences; and Science. U.S. News & World Report ranks Clemson University tied at 74th for 2021 among all national U.S. universities. Clemson University is classified among "R1: Doctoral Universities – Very high research activity."