Martin Luther University of Halle-Wittenberg (German: Martin-Luther-Universität Halle-Wittenberg), also referred to as MLU, is a public, research-oriented university in the cities of Halle and Wittenberg in the State of Saxony-Anhalt, Germany. MLU offers German and international (English) courses leading to academic degrees such as BA, BSc, MA, MSc, doctoral degrees, and Habilitation.

The university was created in 1817 through the merger of the University of Wittenberg (founded in 1502) and the University of Halle (founded in 1694). The university is named after Protestant reformer Martin Luther, who was a professor in Wittenberg. Today, the university itself is located in Halle, while the Leucorea Foundation in Wittenberg serves as MLU's convention centre. Both Halle and Wittenberg are about one hour from Berlin via the Berlin–Halle railway, which offers Intercity-Express (ICE) trains.

The University of Wittenberg (Universität Wittenberg) was founded in 1502 by Frederick the Wise, Elector of Saxony, as the Renaissance was becoming more and more popular. The foundation of the university was heavily criticized, especially when Martin Luther's Ninety-five Theses reached Albert of Brandenburg, the Archbishop of Mainz. Ecclesiastically speaking, the Electorate of Saxony was subordinate to Albert. He criticized the elector for Luther's theses, viewing the recently founded university as a breeding ground for heretical ideas. Under the influence of Philipp Melanchthon, building on the works of Martin Luther, the university became a centre of Protestant Reformation, even incorporating, at one point in time, Luther's house in Wittenberg, the Lutherhaus, as part of the campus. Notable alumni include George Müller, Georg Joachim Rheticus and – in fiction – William Shakespeare's Prince Hamlet and Horatio and Christopher Marlowe's Doctor Faustus.